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CCT007093 PPM1D inhibitor

Catalog No.B3274
Size Price Stock Qty
Evaluation Sample
$28.00
In stock
10mg
$82.00
In stock
25mg
$166.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

CCT007093

Biological Activity

Description CCT007093 is a potent inhibitor of PPM1D (WIP1) with IC50 value of 8.4 μM.
Targets WIP1          
IC50 8.4 μM          

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Chemical Properties

Cas No. 176957-55-4 SDF Download SDF
Chemical Name (2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one
Canonical SMILES C1CC(=CC2=CC=CS2)C(=O)C1=CC3=CC=CS3
Formula C15H12OS2 M.Wt 272.39
Solubility <3.4mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

CCT007093 is a small-molecule chemical inhibitor of PPM1D with IC50 value of 8.4μM [1].

CCT007093 is a thienylidene cyclopentanone and shows a potent inhibition of PPM1D in the in vitro assay when using the recombinant phospho-P38 as a substrate. In cellular assay, CCT007093 shows specificity for MCF-7 cells over HeLa cells. It reduces 40% viability of the cells after 2 days. It is found that the cell death induced by CCT007093 is dependent on P38 kinase activity. CCT007093 mimics the effect of PPM1D RNAi in activating P38 kinase. It induces P38 phosphorylation at 4 h post-exposure in MCF-7 cells and the loss of viability can be rescued by SB203580, the specific P38 inhibitor [1].

References:
[1] Rayter S, Elliott R, Travers J, Rowlands MG, Richardson TB, Boxall K, Jones K, Linardopoulos S, Workman P, Aherne W, Lord CJ, Ashworth A. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27(8):1036-44.