DiscoveryProbe™ Microbiology & Virology-related Compounds Panel
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Featured Products of the Panel
|Catalog No.||Product Name||Summary||Targets||CAS Number||Smiles|
|A8401||Clotrimazole||Antifungal compound||Microbiology &Virology|Antibiotic||23593-75-1||C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4|
|A5790||Cidofovir||Anti-CMV drug;inhibitor of viral DNA synthesis||Microbiology &Virology|CMV||113852-37-2||C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O|
|B1533||BMS-378806||Gp120/CD4 inhibitor||Microbiology &Virology|gp120/CD4||357263-13-9||CC1CN(CCN1C(=O)C(=O)C2=CNC3=NC=CC(=C23)OC)C(=O)C4=CC=CC=C4|
|A3444||GS-9620||TLR-7 agonist||Microbiology &Virology|HBV||1228585-88-3||CCCCOC1=NC2=C(C(=N1)N)NC(=O)CN2CC3=CC(=CC=C3)CN4CCCC4|
|A3546||Ledipasvir||HCV NS5A protein inhibitor||Microbiology &Virology|HCV||1256388-51-8||CC([[email protected]@](/N=C(OC)\O)([H])C(N1CC2(C[[email protected]@]1([H])C3=NC=C(N3)C4=CC5=C(C6=C(C5(F)F)C=C(C7=CC(N8)=C(N=C8[[email protected]]9([H])[[email protected]@]%10([H])CC[[email protected]](N9C([[email protected]](/N=C(OC)\O)([H])C(C)C)=O)([H])C%10)C=C7)C=C6)C=C4)CC2)=O)C|
|B1119||Efavirenz||Reverse transcriptase inhibitor||Microbiology &Virology|HIV||154598-52-4||C1CC1C#CC2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F|
|Download the Microbiology & Virology-related Compounds Panel - XLSX Download the Microbiology & Virology-related Compounds Panel - SDF|
Sofosbuvir (SOF) is a highly efficacious and well-tolerated uridine nucleotide analog that inhibits the hepatitis C virus (HCV) NS5B polymerase enzyme. We describe the validation and utilization of a method to characterize SOF's disposition into various in vivo cell types. Median concentrations in PBMC were 220, 70.2, and 859 fmol/10(6) cells in the monophosphate, diphosphate, and triphosphate fractions, respectively. In contrast, RBC triphosphate concentrations were much lower than those of PBMC, as the median concentration was 2.91 fmol/10(6) cells. The validated method and the data it generates provide novel insight into the cellular disposition of SOF and its phosphorylated anabolites in vivo.
Human cytomegalovirus (HCMV) receptor-ligand interactions and viral entry excite cellular responses such as receptor tyrosine kinase and mitogen-activated protein kinase signaling, cytoskeletal rearrangement, and the induction of transcription factors, prostaglandins, and cytokines. Bi-phasic stimulation of these pathways, excepting interferon, facilitates productive viral infection and likely contributes to viral pathogenesis.