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DiscoveryProbe™ Microbiology & Virology-related Compounds Panel

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A wide range of well-characterized bioactive molecules that covers various targets related to microbiology & virology, including CCR5, HSV and CMV etc. Facilitate your research towards the insights of infection, immune diseases and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.


Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation

Featured Products of the Panel

Catalog No. Product Name Summary Targets CAS Number Smiles
A8401 Clotrimazole Antifungal compound Microbiology &Virology|Antibiotic 23593-75-1 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
A5790 Cidofovir Anti-CMV drug;inhibitor of viral DNA synthesis Microbiology &Virology|CMV 113852-37-2 C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
B1533 BMS-378806 Gp120/CD4 inhibitor Microbiology &Virology|gp120/CD4 357263-13-9 CC1CN(CCN1C(=O)C(=O)C2=CNC3=NC=CC(=C23)OC)C(=O)C4=CC=CC=C4
A3444 GS-9620 TLR-7 agonist Microbiology &Virology|HBV 1228585-88-3 CCCCOC1=NC2=C(C(=N1)N)NC(=O)CN2CC3=CC(=CC=C3)CN4CCCC4
A3546 Ledipasvir HCV NS5A protein inhibitor Microbiology &Virology|HCV 1256388-51-8 CC([[email protected]@](/N=C(OC)\O)([H])C(N1CC2(C[[email protected]@]1([H])C3=NC=C(N3)C4=CC5=C(C6=C(C5(F)F)C=C(C7=CC(N8)=C(N=C8[[email protected]]9([H])[[email protected]@]%10([H])CC[[email protected]](N9C([[email protected]](/N=C(OC)\O)([H])C(C)C)=O)([H])C%10)C=C7)C=C6)C=C4)CC2)=O)C
B1119 Efavirenz Reverse transcriptase inhibitor Microbiology &Virology|HIV 154598-52-4 C1CC1C#CC2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F
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1. Rower JE, Jimmerson LC, Chen X, Zheng JH, Hodara A, Bushman LR, Anderson PL, Kiser JJ. Validation and Application of a Liquid Chromatography-Tandem Mass Spectrometry Method To Determine the Concentrations of Sofosbuvir Anabolites in Cells. Antimicrob Agents Chemother. 2015 Dec;59(12):7671-9.
Sofosbuvir (SOF) is a highly efficacious and well-tolerated uridine nucleotide analog that inhibits the hepatitis C virus (HCV) NS5B polymerase enzyme. We describe the validation and utilization of a method to characterize SOF's disposition into various in vivo cell types. Median concentrations in PBMC were 220, 70.2, and 859 fmol/10(6) cells in the monophosphate, diphosphate, and triphosphate fractions, respectively. In contrast, RBC triphosphate concentrations were much lower than those of PBMC, as the median concentration was 2.91 fmol/10(6) cells. The validated method and the data it generates provide novel insight into the cellular disposition of SOF and its phosphorylated anabolites in vivo.
2. Evers DL, Wang X, Huang ES. Cellular stress and signal transduction responses to human cytomegalovirus infection. Microbes Infect. 2004 Oct;6(12):1084-93.
Human cytomegalovirus (HCMV) receptor-ligand interactions and viral entry excite cellular responses such as receptor tyrosine kinase and mitogen-activated protein kinase signaling, cytoskeletal rearrangement, and the induction of transcription factors, prostaglandins, and cytokines. Bi-phasic stimulation of these pathways, excepting interferon, facilitates productive viral infection and likely contributes to viral pathogenesis.