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IL-21, human recombinant protein

Catalog No.
P1033
IL-21, pleiotropic cytokine, expressed in E.Coli, biologically active.
Grouped product items
SizePriceStock Qty
10ug
$251.00
Ship with 5-10 days
50ug
$878.00
Ship with 5-10 days
1mg
$6,138.00
Ship with 5-10 days

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Background

Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. IL-21 induces the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells, apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling and stimulates IgG production in conjunction with IL-4. Also, IL-21 enhances the anti-tumor activity of CD8+ T-cells and NK cells. The IL21/IL21 R interaction plays important roles in B and T-cell proliferation after antigen stimulation and NK cell maturation.

 The human IL-21 cDNA encodes a 155 aa protein with a 22 aa signal sequence. Recombinant human IL-21 is a homodimeric, non-glycosylated polypeptide containing 133 amino acid residues and has a molecular weight of 15.5 kDa.

Biological Activity

Determined by the dose-dependent stimulation of human peripheral blood mononuclear cells.
ED50 < 5 ng/ml.          

Quality Control

Quality Control & DataSheet

View current batch:
    Purity: ≥90%, by SDS-PAGE and HPLC.
    Endotoxin Level:<0.1 ng/μg

Related Biological Data

IL-21

Related Biological Data

IL-21
 

Description

Gene ID: 59067 Accession #: Q9HBE4
Alternate Names:Human IL-21, IL-21, IL21, IL 21, h-IL-21, rh-IL-21, recombinant human IL-21, recombinant IL-21, IL, interluekin.
Source: Escherichia Coli. M.Wt: 15.5 kDa
Appearance: Lyophilized protein Storage: Store at -20°C
Formulation:Lyophilized (from 1 mg/ml solution containing no additives).
Solubility:Reconstitute in H2O to a concentration of 0.1-1.0 µg/µl (Note: Gently pippetting to dissolve). The solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use.
Shipping Condition: Gel pack. Handling: Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.