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Caspofungin

Catalog No.
B4972
lipopeptide antifungal drug
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$210.00
In stock
5mg
$45.00
In stock
10mg
$80.00
In stock
50mg
$340.00
Ship with 10-15 days

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Background

Caspofungin is an inhibitor of β-1,3-glucan synthase with IC50 value of 0.6 nmol/L in membrane preparations of C. albicans [1, 2]. 

β-1,3-glucan synthase plays a critical role in biosynthesis of β-(1,3)-D-glucan, an essential cell wall component of many pathogenic fungi that is absent in the mammalian host. Inhibition of β-1,3-glucan synthase provides a potential therapeutic option for treating serious and life-threatening fungal infections [1]. 

Caspofungin exhibited inhibitory effect against 400 bloodstream Candida species with MIC90 value of 0.25 μg/mL. Moreover, all azole-resistant isolates were susceptible to Caspofungin at concentrations of ≤ 0.5 μg/mL. In addition, Caspofungin showed a postantifungal effect against C. albicans, which lasted for 6 ~ 8 h, at concentrations of 0.125 ~ 1 μg/mL [2]. 

In 140 patients with mucosal candidiasis, 63% of whom had esophageal involvement and 98% of whom had acquired immunodeficiency syndrome (AIDS), the response rates among the Caspofungin recipients (35, 50, or 70 mg, i.v., q.d., for 7 ~ 14 d) with exclusively oropharyngeal infections was 84% ~ 93%, higher than 67% among those assigned to receive Amphotericin B (0.5 mg/kg, i.v., q.d., for 7 ~ 14 d) [2]. 

References:

[1]. Leonard W R Jr, Belyk K M, Conlon D A, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. The Journal of Organic Chemistry, 2007, 72(7): 2335-2343.

[2]. Deresinski S C, Stevens D A. Caspofungin. Clinical Infectious Diseases, 2003, 36(11): 1445-1457.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1092.33
Cas No.162808-62-0
FormulaC53H89N9O15
Solubility≥48.1mg/mL in DMSO
Chemical Name(2R,6S,11R,12R,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-9-(11,13-dimethyl-2-oxopentadecyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)hexadecahydro-1H-dipyrrolo[2,1-
SDFDownload SDF
Canonical SMILESO=C([[email protected]@H]1C[[email protected]@H](O)CN1C([[email protected]@H](NC(C2CC(CCCCCCCCC(C)CC(CC)C)=O)=O)[[email protected]@H](C)O)=O)N[[email protected]@H]([[email protected]](O)[[email protected]@H](O)C3=CC=C(O)C=C3)C(N[[email protected]@H]([[email protected]](O)CCN)C(N4CC[[email protected]](O)[[email protected]]4C(N[[email protected]@H](NCCN)[[email protected]](O)C2)=O)=O)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Caspofungin

Related Biological Data

Caspofungin