In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cefoperazone is a cephalosporin antibiotic which inhibits rMrp2-mediated [3H]E217βG uptake with an IC50 of 199 μM .
The inhibition profile for cefoperazone was biphasic with IC50, high and IC50, low values of 6.66 ± 3.23 μM and 3.88 ± 1.32 mM, respectively, indicating that cefoperazone may inhibit two binding sites that mediated [3H]E217βG transport . Cefoperazone is a sterile, broad-spectrum, semisynthetic, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. After intravenous administration of 2 g cefoperazone, levels in serum ranged from 202 μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of cefoperazone, the mean peak serum level was111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels were still 2 to 4 μg/mL.Cefoperazone is 90% bound to serum proteins.The apparent volume of distribution was 10 to 13L. The half-life of the drug varied from 1.6 to 2.4 hours, and the serum clearance was between 75 and 96 ml/min .
. Kato Y1,Takahara S,Kato S,Kubo Y,Sai Y,Tamai I,Yabuuchi H,Tsuji A. Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics.Drug Metab Dispos.2008 Jun;36(6):1088-96. doi: 10.1124/dmd.107.019125. Epub 2008 Mar 13.
. Craig WA,Gerber AU. Pharmacokinetics of cefoperazone: a review. Drugs.1981;22Suppl 1:35-45.
|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Solubility||≥64.6mg/mL in DMSO|
|Chemical Name||(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid|
|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
Quality Control & MSDS
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