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Human EPOR / Erythropoietin Receptor Protein (Fc Tag)

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Synonym EPOR , MGC138358
Protein Construction

A DNA sequence encoding the extracellular domain ( Met 1- Pro 250 ) of human erythropoietin receptor (NP_000112.1 ) precursor was fused with the Fc region of human IgG1 at the C-terminus.

Source Human
Expression Host Human Cells
Purity > 90% as determined by SDS-PAGE
Bio-activity Measured by its binding ability in a functional ELISA
Immobilized CD131 at 10 μg/mL ( 100 μl/well ) can bind biotinylated recombinant human EPOR with a linear range of? 0.16 - 4 μg/ml
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Stability Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal Ala 25
Molecular Mass

The recombinant human EPOR/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 460 amino acids and has a predicted molecular mass of 51.0 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhEPOR/Fc monomer is approximately 55-60 kDa due to glycosylation.

Formulation Lyophilized from sterile PBS, 8% sucrose,0.5% Tween-20, pH 7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Storage Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
EPOR Protein Description
Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis , and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR is a type 1 single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPO binding to EPOR triggers auto- or trans-phosphorylation of a protein-tyrosine kinase JAK2 bound to the receptor cytosolic (CT) domain, and subsequently JAK2 activates a variety of intracellular signal substrates including Ras/MAPK, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to function in erythroid cell survival through preventing the PCD, and is also suggested to play a neuroprotective role for its expression in mammalian brains. Aberrantly expressed EPOR is implicated in pathogenesis of various human diseases including erythroleukemia and familial erythrocytosis.