Toggle Nav

D-64131

Catalog No.
A3344
Tubulin polymerization inhibitor
Grouped product items
SizePriceStock Qty
10mg
$121.00
Ship with 10-15 days
50mg
$538.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. [1]

The polymerization of bovine brain tubulin as well as binding of [3H] colchicine to biotinylated αβ-tubulin was dose-dependently inhibited by D-64131. Many cancer cells display abnormal microtubule structures, such as fragmented mitotic spindles or multiple spindle poles after treatment with D-64131. Nuclear blebbing and abnormal nuclear structures typical for apoptotic cells are detectable in many cells treated with D-64131. In nude mice, D-64131 proved to be well tolerated and highly active against the human amelanoic melanoma MEXF 989 tumor xenograft. D-64131 treatment resulted in significant tumor growth inhibition during treatment. [1]

Reference:
1. Beckers T, Reissmann T, Schmidt M et al.  2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 2002 Jun 1;62(11):3113-9.

Chemical Properties

Physical AppearanceYellow crystalline solid
StorageStore at -20°C
M.Wt251.28
Cas No.74588-78-6
FormulaC16H13NO2
SynonymsD 64131;D64131
SolubilitySoluble in DMSO
Chemical Name(5-methoxy-1H-indol-2-yl)(phenyl)methanone
SDFDownload SDF
Canonical SMILESCOC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

D-64131