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Calcium Ionophore I Ca2+-selective ionophore

Catalog No.B6065
Size Price Stock Qty
10mM (in 1mL DMSO)
$100.00
In stock
5mg
$45.00
In stock
10mg
$85.00
In stock
25mg
$190.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Calcium Ionophore I

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Chemical Properties

Cas No. 58801-34-6 SDF Download SDF
Chemical Name (17R,18R)-diethyl 13,17,18,22-tetramethyl-14,21-dioxo-16,19-dioxa-13,22-diazatetratriacontane-1,34-dioate
Canonical SMILES C[[email protected]]([[email protected]](OCC(N(CCCCCCCCCCCC(OCC)=O)C)=O)C)OCC(N(C)CCCCCCCCCCCC(OCC)=O)=O
Formula C38H72N2O8 M.Wt 684.99
Solubility Soluble in DMSO Storage Store at -20°C
Physical Appearance A solution in ethanol Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Calcium Ionophore I, also known as CA 1001 or ETH 1001, is a Ca2+-selective ionophore [1][2].

Ionophores can selectively change the ionic permeability of a membrane and therefore can be used to mimic the properties of the ion carriers normally found in biological membranes and to study membrane function [2].

Calcium Ionophore I is a Ca2+-selective neutral carrier. In Ca2+ loaded IOVs derived from human RBCs, ETH 1001 promoted Ca2+ flux across RBC membranes. The amount of Ca2+ in cells treated with ETH 1001 was significantly higher than in control cells. In the presence of external Ca2+, ETH 1001 was capable of transporting Ca2+ into RBCs [3]. CA 1001 was also used to construction of the Ca2+-selective membrane microelectrode [4][5].

References:
Dagostino M, Lee CO.  Neutral carrier Na+- and Ca2+-selective microelectrodes for intracellular application. Biophys J. 1982 Dec;40(3):199-207.
Caroni P, Gazzotti P, Vuilleumier P, et al.  Ca2+ transport mediated by a synthetic neutral Ca2+ -ionophore in biological membranes. Biochim Biophys Acta. 1977 Nov 1;470(3):437-45.
Hinds TR, Vincenzi FF.  The effect of ETH 1001 on ion fluxes across red blood cell membranes. Cell Calcium. 1985 Jun;6(3):265-79.
Lücke A, Lehmenkühler A, Speckmann EJ.  The influence of the convulsant pentylenetetrazol on Ca2+-selective microelectrodes (neutral carrier ETH 1001). J Neurosci Methods. 1989 Aug;29(2):139-42.
Lee MH, Yoo CL, Lee JS, et al.  Tweezer-type neutral carrier-based calcium-selective membrane electrode with drastically reduced anionic interference. Anal Chem. 2002 Jun 1;74(11):2603-7.