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Cadherin Peptide, avian Role in cell adhesion

Catalog No.A1028
Size Price Stock Qty
1mg
$45.00
In stock
5mg
$135.00
In stock
10mg
$225.00
In stock
25mg
$315.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Cadherin Peptide, avian

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Chemical Properties

Cas No. 127650-08-2 SDF Download SDF
Synonyms H2N-Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-amide
Chemical Name Cadherin Peptide, avian
Canonical SMILES CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)NC(CC1=CN=CN1)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NCC(=O)N)N
Formula C44H75N17O13 M.Wt 1050.17
Solubility >105mg/mL in DMSO or water Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Cadherin Peptide, avian, (C44H75N17O13), a peptide with the sequence Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2, MW= 1050.2. Cadherins (named for "calcium-dependent adhesion") are a class of type-1 transmembrane proteins. They play important roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function. Cadherins are synthesized as polypeptides and undergo many post-translational modifications to become the proteins which mediate cell-cell adhesion and recognition. Cadherins behave as both receptors and ligands. During development, their behavior assists in properly positioning cells - they are responsible for the separation of the different tissue layers, and for cellular migration. In the very early stages of development, E-cadherin (epithelial cadherin) is most greatly expressed. During the next stage, the development of the neuronal plate, N-cadherin (neural cadherin) is expressed and there is a decrease in E-cadherin. Finally, during the development of the notochord and the condensation of somites, E- P- and N-cadherin expression increases. After development, cadherins play a role in maintaining cell and tissue structure, and in cellular movement.

 A1028_1

 Figure1  Formula of b-Interleukin II (44-56)

A1028_2 

 Figure2  The organisation of the cadherin-catenin complex

Ref:

1. Harris, Tony J.C., and Ulrich Tepass. "Adherins Junctions: From Molecules to Morphogenesis" Nature Reviews Molecular Cell Biology. 502-514. July 2010

2. Tepass, Ulrich, et al. "Cadherins in Embryonic and Neural Morphogenisis" Nature Reviews Molecular Cell Biology. November 2000.

3. Tepass, Ulrich, et al. "Cadherins in Embryonic and Neural Morphogenisis" Nature Reviews Molecular Cell Biology. November 2000.