Toggle Nav
APExBIO

BYK 204165

In stock
Catalog No.
A4525
PARP-1 inhibitor,potent and selective
Grouped product items
SizePriceStock Qty
10mg
$231.00
In stock
50mg
$973.00
In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor with pIC50 values of 5.38 and 7.35 for PARP-2 and PARP-1 respectively [1].
PARP1 is a nuclear enzyme activated by strand breaks in DNA and involved in the regulation of various cell processes such as DNA repair, apoptosis, organ dysfunction or necrosis [1].
BYK 204165 (PARP inhibitor XIV) is a cell-permeable isoquinolinedione compound that potently and selectively inhibits PARP1. BYK 204165’s potency is similar or higher than most current standard PARP-1 inhibitors (just slightly lower than PJ34), and it is 100-fold selective for PARP-1 over PARP-2 [1].
BYK 204165 was not tested in vivo because of BYK its poor water solubility.
References:
[1]. Eltze T, Boer R, Wagner T, et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol, 2008, 74(6): 1587-98.

Physical Appearance

Yellow solid

Chemical Properties

StorageDesiccate at 4°C
M.Wt252.27
Cas No.1104546-89-5
FormulaC15H12N2O2
Solubility<25.23mg/ml in DMSO
Chemical Name(4E)-4-[(1-methylpyrrol-2-yl)methylidene]isoquinoline-1,3-dione
SDFDownload SDF
Canonical SMILESCN1C=CC=C1C=C2C3=CC=CC=C3C(=O)NC2=O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

BYK 204165