|Budesonide Anti-inflammatory corticosteroid|
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||51333-22-3||SDF||Download SDF|
|Canonical SMILES||O=C(C([H])([H])O[H])[[email protected]@]12OC(C([H])([H])C([H])([H])C([H])([H])[H])([H])O[[email protected]]1([H])C([H])([H])[[email protected]]([[email protected]@](C([H])([H])C3([H])[H])([H])[[email protected]@]4([H])[[email protected]@](C([H])([H])[H])(C([H])=C5[H])C3=C([H])C5=O)([H])[[email protected]]2(C([H])([H])[H])C([H])([H])[[email protected]]4([H])O[H]|
|Solubility||≥20.2mg/mL in DMSO||Storage||Store at -20°C|
|Physical Appearance||A solid||Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
Budesonide is an anti-inflammatory corticosteroid .
Budesonide has shown the potent glucocorticoid activity and little mineralocorticoid activity. In addition, Budesonide has been reported to have a wide range of inhibitory activities against multiple cells types and mediators involved in allergic and nonallergic-mediated inflammatory. Besides, the anti-inflammatory action of budesonide has been revealed to contribute to the efficacy in asthma. Apart from these, orally inhaled budesonide has been found to be rapidly absorbed in the lungs and that peak concentration is typically reached within 20 minutes. The results have been exhibited that peak plasma concentration is achieved in about 1 to 2 h and the absolute systemic availability is 6%-13% after oral administration of budesonide .
 Ricardo Zollner1*, Eduardo Abib Junior1,2*, Luciana Fernandes Duarte2, Maurício Wesley Perroud2andAntonioRicardo Amarante2. Bioequivalency Study for Inhaled Drugs: A Pharmacodynamic Approac. Bioequivalence & Bioavailability