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Budesonide Anti-inflammatory corticosteroid

Catalog No.B1900
Size Price Stock Qty
10mM (in 1mL DMSO)
$50.00
In stock
50mg
$68.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Budesonide

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Chemical Properties

Cas No. 51333-22-3 SDF Download SDF
Chemical Name (6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-10-propyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one
Canonical SMILES O=C(C([H])([H])O[H])[[email protected]@]12OC(C([H])([H])C([H])([H])C([H])([H])[H])([H])O[[email protected]]1([H])C([H])([H])[[email protected]]([[email protected]@](C([H])([H])C3([H])[H])([H])[[email protected]@]4([H])[[email protected]@](C([H])([H])[H])(C([H])=C5[H])C3=C([H])C5=O)([H])[[email protected]]2(C([H])([H])[H])C([H])([H])[[email protected]]4([H])O[H]
Formula C25H34O6 M.Wt 430.53
Solubility ≥20.2mg/mL in DMSO Storage Store at -20°C
Physical Appearance A solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Budesonide is an anti-inflammatory corticosteroid [1].

Budesonide has shown the potent glucocorticoid activity and little mineralocorticoid activity. In addition, Budesonide has been reported to have a wide range of inhibitory activities against multiple cells types and mediators involved in allergic and nonallergic-mediated inflammatory. Besides, the anti-inflammatory action of budesonide has been revealed to contribute to the efficacy in asthma. Apart from these, orally inhaled budesonide has been found to be rapidly absorbed in the lungs and that peak concentration is typically reached within 20 minutes. The results have been exhibited that peak plasma concentration is achieved in about 1 to 2 h and the absolute systemic availability is 6%-13% after oral administration of budesonide [1].

References:
[1] Ricardo Zollner1*, Eduardo Abib Junior1,2*, Luciana Fernandes Duarte2, Maurício Wesley Perroud2andAntonioRicardo Amarante2. Bioequivalency Study for Inhaled Drugs: A Pharmacodynamic Approac. Bioequivalence & Bioavailability