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Begacestat

In stock
Catalog No.
A4406
γ-secretase inhibitor
Grouped product items
SizePriceStock Qty
10mg
$279.00
In stock
50mg
$1,133.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

γ-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.

Chemical Properties

Physical AppearanceWhite solid
StorageStore at 4°C
M.Wt391.74
Cas No.769169-27-9
FormulaC9H8ClF6NO3S2
SynonymsGSI-953
Solubility<39.17mg/ml in DMSO; <39.17mg/ml in ethanol
Chemical Name5-chloro-N-[(2S)-4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl]thiophene-2-sulfonamide
SDFDownload SDF
Canonical SMILESC1=C(SC(=C1)Cl)S(=O)(=O)NC(CO)C(C(F)(F)F)C(F)(F)F
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Begacestat