|Begacestat γ-secretase inhibitor|
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||769169-27-9||SDF||Download SDF|
|Solubility||<39.17mg/ml in DMSO; <39.17mg/ml in ethanol||Storage||Store at 4°C|
|Physical Appearance||White solid||Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
γ-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.