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Begacestat γ-secretase inhibitor

Catalog No.A4406
Size Price Stock Qty
10mg
$279.00
In stock
50mg
$1,133.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

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Chemical structure

Begacestat

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Chemical Properties

Cas No. 769169-27-9 SDF Download SDF
Synonyms GSI-953
Chemical Name 5-chloro-N-[(2S)-4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl]thiophene-2-sulfonamide
Canonical SMILES C1=C(SC(=C1)Cl)S(=O)(=O)NC(CO)C(C(F)(F)F)C(F)(F)F
Formula C9H8ClF6NO3S2 M.Wt 391.74
Solubility <39.17mg/ml in DMSO; <39.17mg/ml in ethanol Storage Store at 4°C
Physical Appearance White solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

γ-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.