B-Raf inhibitor 1

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B-Raf inhibitor 1 Potent and selective B-Raf inhibitor

Catalog No.B1172

Size	Price	Stock
5mg	$125.00	Please Inquire
10mg	$200.00	Please Inquire
50mg	$873.00	Please Inquire
100mg	$1,570.00	Please Inquire

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Publications citing ApexBio Products

Nature.
2017 Jan 19;541(7637):417-420.

Nature.
2018 Nov;563(7731):407-411.

Nature.
2018 Jun 13.

Nature.
2018 Jun 27.

Nature.
2018 Mar 29;555(7698):673-677.

Nature.
2017 Sep 7;549(7670):96-100.

Nature.
2016 Apr 21;532(7599):398-401.

Science.
2016 Aug 5;353(6299)594-8

Nat Nanotechnol.
2017 Dec;12(12):1190-1198.

Nature Biotechnology.
2017 Jun;35(6):569-576

Nat Med.
2018 Sep 17.

Cell.
Available online 25 October 2018.

Cell.
2018 Sep 27. pii: S0092-8674(18)31183-8.

Cell.
2018 Jun 28;174(1):172-186.e21.

Cell.
2018 Feb 22;172(5):1007-1021.e17.

Cell.
2017 Nov 30;171(6):1284-1300.e21.

Cell.
2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.
2017 Jul 13;170(2):312-323

Nat Med.
2018 Jan 29.

Nat Med.
2017 Nov;23(11):1342-1351.

Cell.
2017 Apr 6;169(2):286-300.

Cell.
2015 Aug 27;162(5):987-1002.

Cell.
2015 Feb 12;160(4):729-44.

Nature Medicine.
2017 Apr;23(4):493-500.

Cancer Cell.
2018 May 14;33(5):905-921.e5.

Cancer Cell.
2018 Apr 9;33(4):752-769.e8.

Cancer Cell.
2018 Mar 12;33(3):401-416.e8.

Cancer Cell.
2017 Aug 14;32(2):253-267.e5.

Nat Methods.
2018 Jul;15(7):523-526.

Cell Stem Cell.
2018 May 3;22(5):769-778.e4.

Cell Stem Cell.
2017 Nov 20. pii: S1934-5909(17)30375-2.

Cancer Cell.
2017 May 8;31(5):635-652.e6.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 98.83%

Chemical structure

B-Raf inhibitor 1

B-Raf inhibitor 1 Dilution Calculator

B-Raf inhibitor 1 Molarity Calculator

Chemical Properties

Cas No.	1093100-40-3	SDF	Download SDF
Chemical Name	1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine
Canonical SMILES	CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6
Formula	C26H19ClN8	M.Wt	478.94
Solubility	≥47.9mg/mL in DMSO	Storage	Store at -20°C
Shipping Condition	Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively.