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AniracetamNootropic drug for senile dementia

Aniracetam

Catalog No. B1210
Size Price Stock Qty
10mM (in 1mL DMSO) $50.00 In stock
50mg $50.00 In stock
100mg $80.00 In stock
250mg $160.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Aniracetam

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Chemical Properties

Cas No. 72432-10-1 SDF Download SDF
Chemical Name 1-(4-methoxybenzoyl)pyrrolidin-2-one
Canonical SMILES COC1=CC=C(C=C1)C(=O)N2CCCC2=O
Formula C12H13NO3 M.Wt 219.24
Solubility Soluble in DMSO > 10 mM Storage Store at -20°C
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Background

Aniracetam is a nootropic drug in senile dementia [1].

Aniracetam (Ro 13-5057) has a piracetam-like chemical structure, 1-p-anisoyl-2-pyrrolidinone. It is selected from a series of related compounds because of its effect in impaired cognitive functions in rodents. In rats, the administration of aniracetam (30mg/kg orally) markedly prevents the CO2 induced impairment of acquisition. It also significantly increases the percentage of rats showing retention of the learned task in both the scopolamine induced transient retrograde amnesia model (50mg/kg orally) and the electroconvulsive shock induced memory disruption model (50mg/kg orally). Besides that, aniracetam can prevent the disruptive effect caused by chloramphenicol or cycloheximide (30mg/kg orally) [1, 2].

References:
[1] MIZUKI Y, YAMADA M, KATO I, et al. Effects of aniracetam, a nootropic drug, in senile dementia. A preliminary report.: A Preliminary Report. The Kurume medical journal, 1984, 31(2): 135-143.
[2] Cumin R, Bandle E F, Gamzu E, et al. Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents. Psychopharmacology, 1982, 78(2): 104-111.