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Angiotensin 1/2 (1-9)

In stock
Catalog No.
A1007
Vasoconstrictor
Grouped product items
SizePriceStock Qty
5mg
$60.00
In stock
10mg
$100.00
In stock
25mg
$140.00
In stock

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Angiotensin I/II (1-9) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS) containing the amino acids 1-9 that are converted from Angiotensin I/II peptide.

Angiotensin I is formed by the action of renin on angiotensinogen, which has 12 amino acids and is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin I. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzymeangiotensin-converting enzyme (ACE), primarily through ACE within the lung.

Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron so that drives blood pressure up.

 A1007_1

Figure1  Formula of Angiotensin I/II (1-9) 

Ref:

1.  Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9. 

2. Richard A. Preston. et. (1998). “Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy”. JAMA. 1998;280(13):1168-1172.

3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1183.32
Cas No.34273-12-6
FormulaC56H78N16O13
SynonymsH2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH
Solubility≥118.3mg/mL in DMSO
Chemical NameAngiotensin 1/2 (1-9)
SDFDownload SDF
Canonical SMILESCCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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Chemical structure

Angiotensin 1/2 (1-9)