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Angiotensin 1/2 (1-6)

In stock
Catalog No.
A1048
Vasoconstrictor
Grouped product items
SizePriceStock Qty
5mg
$60.00
In stock
10mg
$100.00
In stock
25mg
$140.00
In stock

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Angiotensin I/II (1-6) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS) that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide.

Angiotensin I is formed by the action of renin on angiotensinogen, an α-2-globulin with 12 amino acids.  Angiotensinogen is produced constitutively and released into the circulation mainly by the liver. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin I. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by angiotensin-converting enzyme (ACE), primarily by ACE within the lung.

Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron, thereby increasing blood pressure.

 A1048_1

Figure1  Formula of Angiotensin I/II (1-6) 

Ref:

1.  Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9. 

2. Richard A. Preston. et. (1998). “Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy”. JAMA. 1998;280(13):1168-1172.

3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt801.89
Cas No.47896-63-9
FormulaC36H55N11O10
SynonymsH2N-Asp-Arg-Val-Tyr-Ile-His-OH
Solubility≥80.2mg/mL in DMSO
Chemical Name2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7S,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
SDFDownload SDF
Canonical SMILESCC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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Chemical structure

Angiotensin 1/2 (1-6)