|Andrographolide NF-κB signaling Inhibitor|
Sample solution is provided at 25 µL, 10mM.
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Related Compound Libraries
|Cas No.||5508-58-7||SDF||Download SDF|
|Solubility||≥16mg/mL in DMSO||Storage||Store at -20°C|
|Physical Appearance||A solid||Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
IC50: 11.0 ± 0.28 μg/ml for α-glucosidase; 11.3 ± 0.29 μg/ml for α-amylase
Andrographolide is an irreversible antagonist of NF-κB. The nuclear factor NF-κB pathway has been considered as a prototypical proinflammatory signaling pathway, based on the role of NF-κB in the expression of proinflammatory genes including chemokines, cytokines and adhesion molecules.
In vitro: Andrographolide was found to suppress the expression of inducible nitric oxide synthase in a concentration-dependent manner. In the andrographolide-treated group, a reduction of Akt, c-Jun N-terminal kinase and p65 phosphorylation was observed. Andrographolide also caused a decrease in Bcl-2/NF-κb expression and a dose-dependent increase in the expression of Cleaved-Caspase3/Bax protein .
In vivo: Rats were dosed with andrographolide intragastrically for 5 consecutive days in a hepatoprotection study. Results indicated that andrographolide could up-regulate glutamate cysteine ligase catalytic and modifier subunits, heme oxygenase-1, superoxide dismutase-1, glutathione S-transferase protein and mRNA expression in the heart, liver, and kidney .
Clinical trial: N/A
 Wang ZM,Kang YH,Yang X,Wang JF,Zhang Q,Yang BX,Zhao KL,Xu LP,Yang LP,Ma JX,Huang GH,Cai J,Sun XC. Andrographolide radiosensitizes human esophageal cancer cell line ECA109 to radiation in vitro. Dis Esophagus.2016 Jan;29(1):54-61.
 Chen HW,Huang CS,Li CC,Lin AH,Huang YJ,Wang TS,Yao HT,Lii CK. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. Toxicol Appl Pharmacol.2014 Oct 1;280(1):1-9.