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Amyloid β-Protein (1-15) Principal component of amyloid

Catalog No.A1003
Size Price Stock Qty
1mg
$55.00
In stock
5mg
$165.00
In stock
10mg
$275.00
In stock
25mg
$385.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Amyloid β-Protein (1-15)

Amyloid β-Protein (1-15) Dilution Calculator

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Chemical Properties

Cas No. 183745-81-5 SDF Download SDF
Synonyms H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-OH
Canonical SMILES CC(C)C(C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CNC=N2)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)N
Formula C78H107N25O27 M.Wt 1826.86
Solubility ≥182.6mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Research found that amyloid beta-protein circulates in human blood and in cerebrospinal fluid and is deposited into plaques found in the brains of patients with Alzheimer's disease (AD). The aggregation of the beta-amyloid protein into dense plaques on the exterior of brain cells results in destroys of the synapses and conduction of nerve impulses.

Ref:

1. Sisodia SS, Price DL. Role of the beta-amyloid protein in Alzheimer's disease. FASEB J. 1995 Mar; 9(5): 366-70.