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Amyloid Beta-Peptide (12-28) (human)

In stock
Catalog No.
A1123
sequence H2N-VHHQKLVFFAEDVGSNK-OH
Grouped product items
SizePriceStock Qty
1mg
$70.00
In stock
5mg
$210.00
In stock
10mg
$350.00
In stock
25mg
$490.00
In stock

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Amyloid beta (Aβ or Abeta) is a peptide of 36–43 amino acids that is processed from the Amyloid precursor protein. While best known as a component of amyloid plaques in association with Alzheimer's disease, evidence has been found that Aβ is a highly multifunctional peptide with significant non-pathological activity(1). Aβ is the main component of deposits found in the brains of patients with Alzheimer's disease. Brain Aβ is elevated in patients with sporadic Alzheimer’s disease. Aβ is the main constituent of brain parenchymal and vascular amyloid, it contributes to cerebrovascular lesions and is neurotoxic(2).

A1123_1

Figure1  Formula of Amyloid β-Peptide (12-28) (human)

A1123_2

Figuresignal pathway of Amyloid β

Ref:

1. Lahiri DK, Maloney B (September 2010). "Beyond the signaling effect role of amyloid–β42 on the processing of AβPP, and its clinical implications". Exp. Neurol. 225 (1): 51–4.

2. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci. 1 (5): 355–8.

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at -20°C
M.Wt1955.2
Cas No.107015-83-8
FormulaC89H135N25O25
SynonymsVal-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys
Solubility≥195.5mg/mL in DMSO
SDFDownload SDF
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Chemical structure

Amyloid?Beta-Peptide (12-28) (human)