Toggle Nav
Close
  • Menu
  • Setting

Ampicillin sodium

Catalog No.
A2510
β-lactam antibiotic
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$50.00
In stock
1g
$45.00
In stock
5g
$133.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ampicillin sodium is a competitive inhibitor of the enzyme transpeptidase with IC50 value of 1.8 μg/ml [1]. 

Ampicillin is a β-lactam antibiotic that kills bacteria by inhibiting transpeptidase reactions. Transpeptidase is involved in the final stages of cell wall biosynthesis and inhibition of it ultimately leads to cell lysis [1]. 

In E. coli 146 cells treated with ether, Ampicillin showed no significant inhibition on the transpeptidase reaction at concentrations below 0.5 μg/ml, but exhibited 50% inhibition at the concentration of 1.8 μg/ml. In E. coli 146 cells, the minimal inhibitory concentration (MIC) of Ampicillin was 3.1 μg/ml [1]. In E. coli and S. typhi, Ampicillin and Epicillin at concentrations close to MIC values killed bacteria at slower rates than Amoxycillin [2]. 

In experimental mouse infections, oral or subcutaneous treatment of Ampicillin at the dose of 0.2 ml/20 g was significantly more effective than Epicillin and Amoxycillin against the majority of infections [2]. 

References:

[1]. Moore B A, Jevons S, Brammer K W. Inhibition of transpeptidase activity in Escherichia coli by thienamycin. Antimicrobial Agents and Chemotherapy, 1979, 15(6): 831-833.

[2]. Basker M J, Gwynn M N, White A R. Comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. Chemotherapy, 1979, 25(3): 170-180.

Chemical Properties

StorageStore at -20°C
M.Wt 371.4
Cas No.69-52-3
FormulaC16H18N3NaO4S
Solubility≥73.6 mg/mL in DMSO, ≥75.2 mg/mL in EtOH, ≥18.57 mg/mL in H2O
Chemical Namesodium;(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
SDFDownload SDF
Canonical SMILESCC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)[O-])C.[Na+]
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control