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Alfacalcidol Bone resorption inhibitor

Catalog No.B2153
Size Price Stock Qty
10mM (in 1mL DMSO)
$133.00
In stock
5mg
$85.00
In stock
10mg
$140.00
In stock
25mg
$260.00
In stock
100mg
$680.00
In stock
500mg
$2,613.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Chemical structure

Alfacalcidol

Protocol

Animal experiment [1]:

Animal models

ovariectomized rat model of osteoporosis

Preparation method

The solubility of this compound in DMSO is >20.1mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Dosage form

0.05, 0.1, and 0.2 μg/kg; orally administered; five times a week for 12 weeks

Application

In ovariectomized rat model of osteoporosis, Alfacalcidol inhibited osteoclastic bone resorption in a dose-dependent way and maintained or even stimulated bone formation. Alfacalcidol increased bone mineral density and improved mechanical strength more effectively than 17b-estradiol.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1] Shiraishi A1, Takeda S, Masaki T, Higuchi Y, Uchiyama Y, Kubodera N, Sato K, Ikeda K, Nakamura T, Matsumoto T, Ogata E. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J Bone Miner Res. 2000 Apr;15(4):770-9.

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Chemical Properties

Cas No. 41294-56-8 SDF Download SDF
Chemical Name (1R,3S,5E)-5-[(2Z)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Canonical SMILES CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Formula C27H44O2 M.Wt 400.65
Solubility >20.1mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Alfacalcidol is an analogue of Vitamin D and a potent inhibitor of bone resorption [1].

Alfacalcidol has been revealed to play a part in bone and mineral homeostasis via binding to the VDR (vitamin D receptor) in calcium-related target organs, such as intestine, bone, kidney and parathyroid gland. In addition, in a high bone-turnover state after OVX, Alfacalcidol has been reported to inhibit osteoclastic bone resorption at pharmacological doses that do not cause hypercalcemia. Apart from these, Alfacalcidol has shown the stimulative effect to the bone formation. Furthermore, Alfacalcidol has been found to enhance bone mass and bone strength at given serum and urinary calcium levels in the OVX model.

References:
[1] Shiraishi A1, Takeda S, Masaki T, Higuchi Y, Uchiyama Y, Kubodera N, Sato K, Ikeda K, Nakamura T, Matsumoto T, Ogata E. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J Bone Miner Res. 2000 Apr;15(4):770-9.