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AG-370 PDGFR inhibitor

Catalog No.C4539
Size Price Stock Qty
1mg
$54.00
In stock
5mg
$244.00
In stock
10mg
$432.00
In stock
25mg
$946.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

AG-370

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Chemical Properties

Cas No. 134036-53-6 SDF Download SDF
Synonyms NSC 651712
Chemical Name 3-amino-4-(1H-indol-5-ylmethylene)-2-pentenetricarbonitrile
Canonical SMILES c12c(ccc(c1)/C=C(\C(=C(\C#N)C#N)N)C#N)[nH]cc2
Formula C15H9N5 M.Wt 259.3
Solubility ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide Storage Store at -20°C
Physical Appearance A crystalline solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

IC50: 20 μM for PDGF receptor kinase in human bone marrow fibroblasts

AG-370 is a tyrphostin PDGFR inhibitor.

Protein tyrosine kinase inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of protein tyrosine kinases. Tyrphostins are a class of antiproliferative agents selectively inhibiting protein tyrosine kinases of key growth factors including epidermal growth factor or platelet-derived growth factor (PDGF) via blocking the phosphorylation of tyrosine residues.

In vitro: Previous study found that AG-370 inhibited PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates that coprecipitated with the PDGF receptor in digitonin-permeabilized fibroblasts and in intact fibroblasts. When compared with AG18, a potent EGF receptor blocker, AG370 was more efficient in inhibiting PDGF-induced proliferation of fibroblasts and phosphorylation of the intracellular protein substrates. Under the conditions in which AG370 could inhibit PDGF-induced mitogenesis and phosphorylation, AG18 did not alter [125I]PDGF internalization and enhance [125I]PDGF binding. These findings suggested that AG370 might have a therapeutic potential for treatment of diseases involving abnormal cellular proliferation induced by PDGF [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Bryckaert, M. C.,Eldor, A.,Fontenay, M., et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Experimental Cell Research 199, 255-261 (1992).