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Afatinib dimaleate

Catalog No.
A3145
EGFR inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$60.00
In stock
5mg
$41.00
In stock
10mg
$68.00
In stock
50mg
$97.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt718.08
Cas No.850140-73-7
FormulaC32H33ClFN5O11
SynonymsBIBW 2992MA2;BIBW-2992;BIBW2992;BIBW 2992;Afatinib
Solubility≥35.9 mg/mL in DMSO, ≥6.39 mg/mL in EtOH with ultrasonic and warming, ≥147.2 mg/mL in H2O
Chemical Name(Z)-but-2-enedioic acid;(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
SDFDownload SDF
Canonical SMILESCN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Afatinib dimaleate

Related Biological Data

Afatinib dimaleate

Related Biological Data

Afatinib dimaleate