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Acetyl Angiotensinogen (1-14), porcine

In stock
Catalog No.
A1034
Angiotensinogen precursor
Grouped product items
SizePriceStock Qty
5mg
$45.00
In stock
10mg
$75.00
In stock
25mg
$105.00
In stock

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Acetyl Angiotensinogen (1-14),porcine, (C87H125N21O21) is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH, MW= 1801.05. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. Pre-angiotensinogen is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure(1). The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Angiotensin II is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia(2). Mutations in the gene are associated with susceptibility to essential hypertension and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the gene have also been associated with non-familial structural atrial fibrillation and inflammatory bowel disease.

A1034_1

Figure1  Formula of Acetyl Angiotensinogen (1-14),porcine

 A1034_2

Figure2  The renin–angiotensin–aldosterone system

Ref:

1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.

2. Skurk T, Lee YM, Hauner H (May 2001). "Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture". Hypertension 37 (5): 1336–40.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1801.05
Cas No.66641-26-7
FormulaC87H125N21O21
SynonymsAc-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH
Solubility≥180.1mg/mL in DMSO
SDFDownload SDF
Canonical SMILESCCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Chemical structure

Acetyl Angiotensinogen (1-14), porcine