4SC-202|Class I HDAC inhibitor|CAS# 1186222-89-8

Size	Price	Stock
10mg	$150.00	In stock
5mg	$100.00	In stock
50mg	$450.00	In stock
100mg	$700.00	In stock

Publications citing ApexBio Products

Nature.
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2017 Sep 7;549(7670):96-100.

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2016 Apr 21;532(7599):398-401.

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2016 Aug 5;353(6299)594-8

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2017 Jun;35(6):569-576

Cell.
2018 Jun 28;174(1):172-186.e21.

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2018 Feb 22;172(5):1007-1021.e17.

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2017 Nov 30;171(6):1284-1300.e21.

Cell.
2017 Aug 17. pii: S0092-8674(17)30869-3.

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Nature Medicine.
2017 Apr;23(4):493-500.

Cancer Cell.
2018 May 14;33(5):905-921.e5.

Cancer Cell.
2018 Apr 9;33(4):752-769.e8.

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2018 Jan 16;48(1):59-74.e5.

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2016 Jan 19;44(1):88-102

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2018 Feb;20(2):186-197.

Quality Control

Quality Control & MSDS

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Purity = 98.49%

Chemical structure

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Chemical Properties

Cas No.	1186222-89-8	SDF	N/A
Synonyms	N/A
Chemical Name	N/A
Canonical SMILES	N/A
Formula	C30H29N5O6S2	M.Wt	619.71
Solubility	Soluble in DMSO	Storage	Store at -20°C
Shipping Condition	Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

4SC-202 is a selective, potent and orally available inhibitor of histone deacetylases (HDAC) specific for class I HDAC isoenzymes with an IC50 value of about 1μM [1].

4SC-202 has been reported to selectively inhibit the recombinant class I HDAC isoenzymes with IC50 values of 1.2μM, 1.12μM and 0.57μM for HDAC-1, HDAC-2 and HDAC-3, respectively. In vitro studies, 4SC-202 has been revealed to induce hyperacetylation of histone H3 in a concentration-dependent fashion with an EC50 values of 1.1μM in HeLa and RKO cell lines. In addition, 4SC-202 has been demonstrated to induce a G2/M cell cycle arrest and enhance in sub G1 cells. In other words, 4SC-202 can induce the apoptotic in NSCLS cell lines. 4SC-202 has been noted to suppress proliferative activity in human cancer cell lines with a mean IC50 of 0.7μM.

In vivo studies, 4SC-202 has shown a good tolerability and dose-dependent effect on anti-tumour activity compared with other inhibitors in the A549NSCLC xenograft model and the RKO27 colon carcinoma model [1].

References:
[1] Henning S W, Doblhofer R, Kohlhof H, et al. 178 Preclinical characterization of 4SC-202, a novel isotype specific HDAC inhibitor[J]. European Journal of Cancer Supplements, 2010, 8(7): 61.