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4'-Demethylepipodophyllotoxin Anti-cancer drug

Catalog No.A3123
Size Price Stock Qty
10mM (in 1mL DMSO)
$50.00
In stock
500mg
$130.00
In stock
1g
$187.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Chemical structure

4

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Chemical Properties

Cas No. 6559-91-7 SDF Download SDF
Synonyms 4'-O-demethylepipodophyllotoxin;4'-DMEP
Chemical Name 6-oxo-1H-pyrazine-3-carboxylic acid
Canonical SMILES COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Formula C21H20O8 M.Wt 400.38
Solubility >83.3mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Description: IC50 Value: 0.31uM(EC50 for HL60 cell, MTT assay, 48h); 0.37uM(EC50 for HepG2 cell, MTT assay, 48h) [1] 4'-demethylepipodophyllotoxin is a key intermediate compounds for the preparation of podophyllotoxin-type anti-cancer drugs. in vitro: 4-TMP-DMEP showed strong cytotoxicity activity against the above-mentioned five tumor cell lines. The EC50s of 4-TMP-DMEP against these tumor cell lines ranged from 0.24 to 0.11 μM, which were 0.29 to 3618 times lower than that of DMEP [1]. in vivo: Treatment of animals with DMEP (until the end of the experiment), 30 min before TPA treatment, significantly reduced the tumor incidence, tumor volume and the conversion efficiency of papillomas to squamous cell carcinomas. The tumor formation and growth was also delayed by DMEP pre-treatment [2]. Clinical trial: N/A