Urokinase inhibitor, potent and specific
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||14279-91-5||SDF||Download SDF|
|Solubility||Soluble to 100 mM in H2O||Storage||Store at RT|
|Physical Appearance||White crystalline solid||Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase .
Urokinase is a serine protease. Its primary physiological substrate is plasminogen, which is an inactive form of plasmin. Urokinase plays an important role in vascular diseases and cancer.
4-Chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with Ki value of 6.07 μM and 120 μM, respectively .
. Yang H, Henkin J, Kim KH, et al. Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. J Med Chem, 1990, 33(11): 2956-2961.