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4-Chlorophenylguanidine hydrochloride
Urokinase inhibitor, potent and specific

Catalog No.A4445
Size Price Stock Qty
100mg
$245.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

4-Chlorophenylguanidine hydrochloride

4-Chlorophenylguanidine hydrochloride Dilution Calculator

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Chemical Properties

Cas No. 14279-91-5 SDF Download SDF
Chemical Name 2-(4-chlorophenyl)guanidine;hydrochloride
Canonical SMILES C1=CC(=CC=C1N=C(N)N)Cl.Cl
Formula C7H8ClN3.HCl M.Wt 206.07
Solubility Soluble to 100 mM in sterile water Storage Store at RT
Physical Appearance White crystalline solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].

Urokinase is a serine protease. Its primary physiological substrate is plasminogen, which is an inactive form of plasmin. Urokinase plays an important role in vascular diseases and cancer.

4-Chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with Ki value of 6.07 μM and 120 μM, respectively [1].

Reference:
[1].  Yang H, Henkin J, Kim KH, et al. Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. J Med Chem, 1990, 33(11): 2956-2961.