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4-Chlorophenylguanidine hydrochloride

Catalog No.
Urokinase inhibitor, potent and specific
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4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].

Urokinase is a serine protease. Its primary physiological substrate is plasminogen, which is an inactive form of plasmin. Urokinase plays an important role in vascular diseases and cancer.

4-Chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with Ki value of 6.07 μM and 120 μM, respectively [1].

[1].  Yang H, Henkin J, Kim KH, et al. Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. J Med Chem, 1990, 33(11): 2956-2961.

Chemical Properties

Physical AppearanceWhite crystalline solid
StorageStore at RT
Cas No.14279-91-5
SolubilitySoluble to 100 mM in H2O
Chemical Name2-(4-chlorophenyl)guanidine;hydrochloride
SDFDownload SDF
Canonical SMILESC1=CC(=CC=C1N=C(N)N)Cl.Cl
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

4-Chlorophenylguanidine hydrochloride