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active against numerous plant pathogenic fungi, viruses, bacteria, and nematodes
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2,4-Diacetylphloroglucinol is an agent against various plant pathogenic fungi, viruses, bacteria, and nematodes.

2,4-Diacetylphloroglucinol, a non-nitrogen-containing compound produced by some isolates of P. fluorescens, has been used to increase crop yield by controlling plant root diseases.

In vitro: A previous study was conducted to determine if 2,4-diacetylphloroglucinol was toxic to selected nematodes. The plant-parasitic nematodes including Pratylenchus scribneri and Xiphinema americanum, Heterodera glycines, Meloidogyne incognita, and the bacterial-feeding nematodes such as Pristionchus pacificus, Caenorhabditis elegans, and Rhabditis rainai, were found to be immersed in concentrations ranging from 0 to 100 μg/ml of 2,4-diacetylphloroglucinol. Moreove, the egg hatch and viability of juveniles and adults were determined, and the results showed that 2,4-diacetylphloroglucinol was toxic to X. americanum adults with an LD50 of 8.3 μg/ml. 2,4-Diacetylphloroglucinol could decrease M. incognita egg hatch, but stimulated C. elegans hatch. Whereas, the viability of M. incognita J2 and of C. elegans J1 and adults was not affected. There were no observed effects on the other nematodes. These findings indicated that 2,4-diacetylphloroglucinol was not toxic to all nematodes, and did not affect the tested species of beneficial bacterial-feeding nematodes [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

[1] Meyer, S. L.F.,Halbrendt, J.M.,Carta, L.K., et al. Toxicity of 2,4-diacetylphloroglucinol (DAPG) to plant-parasitic and bacterial-feeding nematodes. Journal of Nematology 41(4), 274-280 (2009).

Chemical Properties

StorageStore at -20°C
Cas No.2161-86-6
Solubility≥11.55mg/mL in DMSO
Chemical Name1,1'-(2,4,6-trihydroxy-1,3-phenylene)bis-ethanone
SDFDownload SDF
Canonical SMILESOC1=C(C(C)=O)C(O)=C(C(C)=O)C(O)=C1
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure