Bcl-XL protein expression downregulator
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||418788-90-6||SDF||Download SDF|
|Chemical Name||2-((3-(2,3-dichlorophenoxy)propyl)amino)ethanol hydrochloride|
|Solubility||Soluble to 100 mM in sterile water||Storage||Desiccate at -20°C|
|Physical Appearance||White solid||Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.