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10-DAB (10-Deacetylbaccatin)
Precursor of antitumor compound Palitaxel and Docetaxel

Catalog No.A4395
Size Price Stock Qty
10mM (in 1mL DMSO)
$210.00
In stock
Evaluation Sample
$28.00
In stock
5mg
$100.00
In stock
25mg
$400.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

10-DAB (10-Deacetylbaccatin)

Biological Activity

Description 10-DAB (10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate.
Targets Cytoskeleton          
IC50            

10-DAB (10-Deacetylbaccatin) Dilution Calculator

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10-DAB (10-Deacetylbaccatin) Molarity Calculator

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Chemical Properties

Cas No. 32981-86-5 SDF Download SDF
Synonyms 10-Deacetylbaccatin, 10-Deacetylbaccatine III, 10-DEACETYLBACCATIN-III
Chemical Name (2aR,4R,4aS,6S,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Canonical SMILES O[[email protected]](C(C)(C)C1=C(C)[[email protected]]2O)(C2)[[email protected]]([[email protected]@H]([[email protected]@](C([[email protected]]1O)=O)(C)[[email protected]@H]3O)[[email protected]]4([[email protected]@H](C3)OC4)OC(C)=O)OC(C5=CC=CC=C5)=O
Formula C29H36O10 M.Wt 544.59
Solubility >22.3mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus. Due to the low availability of taxol from its natural sources, 10-DAB is used as a raw material for the preparation of taxol and its derivatives. Being easily extracted from the annual cute of the yew leaves, 10-DAB has a very folded chemical structure with the α hydroxyl group hindered at C-13 easily to form a hydrogen bond with the 4α acetyl group.

Reference

F. Gueritte-Voegelein, V. Senilh, B. David, D. Guenard and P. Potier. Chemical studies of 10-deacetyl baccatin III hemisynthesis of taxol derivatives. Tetrahedron 1986; 42(16): 4451-4460